Mission of the lab
Science: We want to unravel basic mechanisms involved in human development and homeostasis.
Culture: We thrive to promote excellent science education in the inclusive environment.
Experimental work will be carried out using stem cell models, high throughput sequencing technologies (RNA-seq, ATAC-seq, TT-seq), CRISPR-Cas9 mediated genome editing, and bioinformatics, to understand the mechanisms that underlie nascent RNAPII transcription during development and in genome stability.
Selected publications
1 joint first author
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Maslon MM1, Heras SR1, Bellora N, Eyras E, Cáceres JF. The translational landscape of the splicing factor SRSF1 and its role in mitosis. Elife. 2014 May 6;3:e02028. doi: 10.7554/eLife.02028. Online ahead of print. PMID: 24842991
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Haward F1, Maslon MM1, Yeyati PL1, Bellora N, Hansen JN, Aitken S, Lawson J, von Kriegsheim A, Wachten D, Mill P, Adams IR, Caceres JF. Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function. Elife. 2021 Aug 2;10:e65104. doi: 10.7554/eLife.65104. PMID: 34338635
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Maslon MM, Braunschweig U, Aitken S, Mann AR, Kilaanowski F, Hunter CJ, Blencowe BJ, Kornblihtt AR, Adams IR, Cáceres JF. A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes. EMBO J. 2019 May 2;38(9):e101244. doi: 10.15252/embj.2018101244. Epub 2019 Apr 15. PMID: 30988016 https://www.embopress.org/doi/full/10.15252/embj.2018101244